Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023394 | 0.76 | HMGCR (0.34) | HMGCR | |
| SCHEMBL3551837 | 0.75 | HMGCR (0.39) | HMGCR | |
| SCHEMBL6024098 | 0.74 | HMGCR (0.33) | HMGCR | |
| SCHEMBL9346100 | 0.72 | ALOX5 (0.35) | — | |
| SCHEMBL7842427 | 0.70 | TYR (0.33) | — | |
| SCHEMBL814614 | 0.69 | — | — | |
| SCHEMBL3544366 | 0.69 | HMGCR (0.43) | HMGCR | |
| SCHEMBL6023375 | 0.68 | — | — | |
| SCHEMBL8476328 | 0.67 | PDE4B (0.40) | — | |
| SCHEMBL8475248 | 0.66 | MGAM (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880523-B1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-0880523-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997029109-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-14 | — | — | WO | disclosed |