Tetrabuthylammonium

Tetrabuthylammonium

SCHEMBL6027186

CCCC[N+](CCCC)(CCCC)CCCC.Cc1cccc(C(=O)NCCO)n1.[F-]

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.50
HPGD P15428 2/20 0.47
MAPK1 P28482 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
GRM5 P41594 1/20 0.45
LMNA P02545 2/20 0.44
HTR1A P08908 2/20 0.41
HTR2A P28223 2/20 0.41
DRD3 P35462 1/20 0.41
CNR1 P21554 2/20 0.41
CTSA P10619 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NAAA Q02083 1/20 0.39
NPC1 O15118 1/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39
RAB9A P51151 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TSHR P16473 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6451392 0.85 P2RX7 (0.67) P2RX7HPGDGRM5LMNAHTR1A
SCHEMBL9967794 0.84 HPGD (0.62) P2RX7HPGDMAPK1NPSR1GRM5
SCHEMBL10707099 0.75 P2RX7 (0.65) P2RX7HPGDGRM5LMNAHTR1A
SCHEMBL30545065 0.75 HPGD (0.64) HPGDMAPK1NPSR1LMNACNR1
SCHEMBL12163955 0.75 P2RX7 (0.69) P2RX7HPGDNPSR1GRM5LMNA
SCHEMBL18157897 0.75 LMNA (0.68) HPGDMAPK1NPSR1LMNADRD3
SCHEMBL7654754 0.74 LMNA (0.66) P2RX7HPGDLMNACNR1SMN1; SMN2
SCHEMBL30695493 0.74 P2RX7 (0.63) P2RX7HPGDMAPK1NPSR1GRM5
Hydrochloric Acid SCHEMBL10709499 0.73 P2RX7 (0.66) P2RX7HPGDGRM5LMNAHTR1A
SCHEMBL6027124 0.72 P2RX7 (0.59) P2RX7HPGDGRM5LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1696915-A1 BENZENESULFONYLAMINO-PYRIDIN-2-YL DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11-BETA-HSD-1) FOR THE TREATMENT OF DIABETES AND OBESITY Pfizer, Inc. (US) 2006-09-06 EP disclosed
WO-2005060963-A1 BENZENESULFONYLAMINO-PYRIDIN-2-YL DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11-BETA-HSD-1) FOR THE TREATMENT OF DIABETES AND OBESITY PFIZER INC. (US) 2005-07-07 WO disclosed