Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6451392 | 0.87 | P2RX7 (0.67) | LMNAALDH1A1KDM4EMAPTCASP1 | |
| SCHEMBL14371962 | 0.87 | ALDH1A1 (0.65) | LMNAALDH1A1KDM4EMAPTCASP1 | |
| SCHEMBL23015720 | 0.84 | LMNA (0.50) | LMNAALDH1A1KDM4EMAPTCASP1 | |
| SCHEMBL15580847 | 0.84 | LMNA (0.62) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL29793824 | 0.84 | LMNA (0.62) | LMNAALDH1A1POLBCA1CA2 | |
| SCHEMBL23015719 | 0.83 | LMNA (0.49) | LMNAALDH1A1KDM4EMAPTCASP1 | |
| SCHEMBL13116574 | 0.81 | HPGD (0.68) | LMNAALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL18157897 | 0.81 | LMNA (0.68) | LMNAKDM4EHPGDTSHRHTT | |
| SCHEMBL178271 | 0.80 | LMNA (0.57) | LMNAALDH1A1POLBCA1CA2 | |
| SCHEMBL20729906 | 0.80 | LMNA (0.57) | LMNAALDH1A1KDM4ECNR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |