Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027212 | 0.89 | KDR (0.55) | GRM4HDAC6KDRKCNK3KCNK9 | |
| SCHEMBL6889061 | 0.86 | GRM4 (0.56) | GRM4HDAC6KDRKCNK3KCNK9 | |
| SCHEMBL6885328 | 0.85 | KDR (0.55) | GRM4HDAC6KDRKCNK3KCNK9 | |
| SCHEMBL1624812 | 0.73 | GRM4 (0.57) | GRM4HDAC6 | |
| SCHEMBL31660405 | 0.72 | BACE1 (0.61) | KCNK3KCNK9BACE1SMN1; SMN2NPC1 | |
| SCHEMBL26094468 | 0.72 | BACE1 (0.61) | KCNK3KCNK9BACE1SMN1; SMN2NPC1 | |
| SCHEMBL6030750 | 0.70 | RAB9A (0.62) | GRM4KDRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL20425479 | 0.69 | ADORA3 (0.63) | KCNK3KCNK9BACE1SMN1; SMN2ALOX15 | |
| SCHEMBL7990375 | 0.69 | KDR (0.84) | GRM4HDAC6KDRKCNK3KCNK9 | |
| SCHEMBL19443380 | 0.69 | LMNA (0.48) | BACE1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613310-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | Avanir Pharmaceuticals (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004091610-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | AVANIR PHARMACEUTICALS (US) | 2004-10-28 | — | — | WO | disclosed |