Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172960 | 0.85 | SIGMAR1 (0.49) | SIGMAR1HRH3ADAM10MMP2MMP8 | |
| SCHEMBL2174013 | 0.84 | ADAM10 (0.60) | SIGMAR1HRH3ADAM10MMP2MMP8 | |
| SCHEMBL2172947 | 0.84 | ADAM10 (0.60) | SIGMAR1HRH3ADAM10MMP2MMP8 | |
| SCHEMBL2174893 | 0.77 | ADAM10 (0.56) | SIGMAR1ADAM10MMP2MMP8MMP12 | |
| SCHEMBL3458394 | 0.77 | ADAM10 (0.56) | SIGMAR1ADAM10MMP2MMP8MMP12 | |
| SCHEMBL2172796 | 0.77 | ADAM10 (0.56) | SIGMAR1ADAM10MMP2MMP8MMP12 | |
| SCHEMBL3458397 | 0.77 | ADAM10 (0.56) | SIGMAR1ADAM10MMP2MMP8MMP12 | |
| SCHEMBL2173968 | 0.74 | ADAM10 (0.56) | SIGMAR1ADAM10MMP2MMP8MMP12 | |
| SCHEMBL10143901 | 0.74 | SIGMAR1 (0.67) | SIGMAR1HRH3ADAM10RAB9ANPC1 | |
| SCHEMBL13015347 | 0.73 | RAB9A (0.52) | SIGMAR1ADAM10MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |