Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.80 |
| ▸ | IL1RN | P18510 | 1/20 | 0.80 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | PKM | P14618 | 1/20 | 0.74 |
| ▸ | CA12 | O43570 | 4/20 | 0.61 |
| ▸ | CA9 | Q16790 | 4/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | PGR | P06401 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenyl(Phenylsulfonyl)Amine SCHEMBL114765 | 0.89 | KEAP1 (1.00) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL25031372 | 0.89 | KEAP1 (1.00) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL27503772 | 0.87 | KEAP1 (0.95) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL6399560 | 0.87 | KEAP1 (0.95) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL11513007 | 0.87 | KEAP1 (0.95) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL9001182 | 0.85 | KMT2A (1.00) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL810795 | 0.85 | KMT2A (0.91) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL28862871 | 0.83 | KEAP1 (0.71) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL27625489 | 0.82 | KEAP1 (0.77) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL3686387 | 0.82 | KMT2A (0.84) | KEAP1IL1RNERAP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709007-A1 | N-4-(6-(HETEO)ARYL-PYRIMIDIN-4-YLAMINOPHENYL)-BENZENESULFONAMIDES AS KINASE INHIBITORS | Altana Pharma AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070900-A1 | N-4-(6- (HETEO) ARYL-PYRIMIDIN-4-YLAMINOPHENYL) -BEZENESULFONAMIDES AS KINASE INHIBITORS | ALTANA PHARMA AG (DE) | 2005-08-04 | — | — | WO | disclosed |