Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556324 | 0.91 | MEN1 (0.46) | ABCG2ABCB1ABCC1MAPTBCHE | |
| SCHEMBL5556164 | 0.88 | ALDH1A1 (0.41) | ABCG2POLBABCB1ABCC1ALDH1A1 | |
| SCHEMBL5561157 | 0.88 | RAB9A (0.44) | ABCG2POLBABCB1ABCC1ALDH1A1 | |
| SCHEMBL5556320 | 0.86 | LMNA (0.44) | ABCG2ALDH1A1MAPTL3MBTL1NPC1 | |
| SCHEMBL5562035 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL5562108 | 0.80 | MEN1 (0.48) | ABCG2MAPTHCRTR2NPC1RAB9A | |
| SCHEMBL5556348 | 0.78 | MTNR1A (0.41) | ABCG2ABCB1ABCC1ALDH1A1MAPT | |
| SCHEMBL5561282 | 0.77 | MEN1 (0.50) | ALDH1A1MAPTL3MBTL1BCHEACHE | |
| SCHEMBL5562105 | 0.77 | LMNA (0.44) | ABCG2ALDH1A1MAPTL3MBTL1MTNR1A | |
| SCHEMBL5561897 | 0.75 | MEN1 (0.47) | MAPTBCHEACHEHCRTR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631296-A1 | 2,3,4,5-TETRAHYDROBENZO[F][1,4]OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004100958-A1 | 2, 3, 4, 5-TETRAHYDROBENZO[F][1, 4]OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | WO | disclosed |