Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6029200 | 0.92 | ROCK2 (0.38) | ROCK2ROCK1AKT1CDK2IKBKB | |
| SCHEMBL6029151 | 0.89 | CHEK1 (0.39) | MAPK1ROCK2ROCK1AKT1CDK2 | |
| SCHEMBL6029125 | 0.89 | MAPK1 (0.38) | MAPK1OPRK1ROCK2ROCK1CCR3 | |
| SCHEMBL7827088 | 0.88 | DYRK1A (0.39) | ROCK2ROCK1AKT1CDK2IKBKB | |
| SCHEMBL6030392 | 0.87 | CHEK1 (0.41) | AKT1CDK2CDK9 | |
| SCHEMBL6029349 | 0.87 | MAPK1 (0.38) | MAPK1OPRK1ROCK2ROCK1TP53 | |
| SCHEMBL7829880 | 0.84 | AKT1 (0.42) | ROCK2ROCK1AKT1IKBKBSLC6A2 | |
| Hydrochloric Acid SCHEMBL7833338 | 0.84 | AKT1 (0.42) | ROCK2ROCK1AKT1IKBKBSLC6A2 | |
| SCHEMBL6028227 | 0.82 | LMNA (0.41) | MAPK1ROCK2ROCK1TP53MAPT | |
| SCHEMBL6029616 | 0.81 | CDK2 (0.37) | ROCK2ROCK1AKT1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984643-B2 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2006-01-10 | — | — | US | disclosed |