Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.63 |
| ▸ | HPGD | P15428 | 11/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.63 |
| ▸ | CASP1 | P29466 | 8/20 | 0.63 |
| ▸ | CASP7 | P55210 | 8/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | ESR1 | P03372 | 2/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030811 | 0.85 | KDM4E (0.69) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL13401733 | 0.82 | KDM4E (1.00) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL6030690 | 0.79 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL31560205 | 0.76 | ALDH1A1 (0.67) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL1718921 | 0.75 | ALDH1A1 (0.61) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4206860 | 0.75 | HPGD (1.00) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4216963 | 0.75 | HPGD (1.00) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL6030114 | 0.75 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL2543331 | 0.75 | ALDH1A1 (0.74) | KDM4ETDP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4204320 | 0.74 | HPGD (0.84) | KDM4ETDP1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098335-B2 | Pyrazolopyrimidine compositions | ICAGEN, INC. (US) | 2006-08-29 | — | — | US | disclosed |
| US-20050215569-A1 | Pyrazolopyrimidines | ICAGEN, INC. (US) | 2005-09-29 | — | — | US | disclosed |
| US-6833371-B2 | Contacting cell with a sodium channel-inhibiting amount of a compound comprising a pyrazolopyrimidine moiety for decreasing ion flow through a voltage-dependent sodium channel in a cell | ICAGEN, INC. | 2004-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215569-A1 | Pyrazolopyrimidines | SCN3A, TRPV3, P2RX3 | KDM4E 2962/4885TDP1 2299/4885ALDH1A1 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.