Phthalic Acid

Phthalic Acid

SCHEMBL6032841

C=CC(C/C=C/C(=O)O)C(=O)O.O=C(O)c1ccccc1C(=O)O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
ALOX15 P16050 1/20 0.42
CYP2C19 P33261 1/20 0.38
MAPT P10636 2/20 0.37
HDAC8 Q9BY41 2/20 0.37
KMT2A Q03164 2/20 0.37
AKR1C3 P42330 2/20 0.36
KDM4E B2RXH2 3/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 1/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
HMGB1 P09429 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
CA7 P43166 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CA9 Q16790 1/20 0.34
NAPRT Q6XQN6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10980180 0.84 ALDH1A1 (0.38) ALDH1A1ALOX15CYP2C19MAPTHDAC8
SCHEMBL1618931 0.83 TSHR (0.44) APEX1
SCHEMBL11372036 0.83 TSHR (0.44) APEX1
Phthalic Acid SCHEMBL368309 0.79 ALDH1A1 (0.50) ALDH1A1ALOX15CYP2C19MAPTHDAC8
Oxirane SCHEMBL10479243 0.76 GABRR1 (0.38) APEX1
Phthalic Acid SCHEMBL9331101 0.73 ALDH1A1 (0.61) ALDH1A1ALOX15MAPTHDAC8KMT2A
Phthalic Acid SCHEMBL28724935 0.72 ALDH1A1 (0.67) ALDH1A1ALOX15MAPTHDAC8AKR1C3
Phthalic Acid SCHEMBL33468 0.72 ALDH1A1 (0.74) ALDH1A1ALOX15MAPTHDAC8AKR1C3
Phthalic Acid SCHEMBL33470 0.72 ALDH1A1 (0.74) ALDH1A1ALOX15MAPTHDAC8AKR1C3
Phthalic Acid SCHEMBL9241582 0.72 ALDH1A1 (0.54) ALDH1A1ALOX15MAPTHDAC8KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0153105-B1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM BENZON PHARMA A/S (DK) 1992-09-09 EP claimed
EP-0153105-A2 Diffusion coated multiple-units dosage form BENZON PHARMA A/S (DK) 1985-08-28 EP claimed
EP-0153104-A2 Diffusion coated multiple-units dosage form BENZON PHARMA A/S (DK) 1985-08-28 EP claimed
WO-1985003437-A1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM A/S ALFRED BENZON (DK) 1985-08-15 WO claimed
US-7070803-B2 Controlled release pharmaceutical composition for oral use containing midodrine and/or active metabolite, desglymidodrine NYCOMED AUSTRIA GMBH (AT) 2006-07-04 US disclosed
EP-1267841-B1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION CONTAINING MIDODRINE AND/OR DESGLYMIDODRINE NYCOMED AUSTRIA GMBH (AT) 2004-11-24 EP disclosed
US-6761904-B2 CONTROLLED RELEASE FOR FAST PEAK PLASMA CONCENTRATION OF THE ACTIVE METABOLITE DESGLYMIDODRINE; TREATING ORTHOSTAIC HYPOTENSION AND/OR URINARY INCONTINENCE NYCOMED AUSTRIA GMBH (AT) 2004-07-13 US disclosed
EP-1017370-B1 MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs) NYCOMED DANMARK APS (DK) 2003-10-29 EP disclosed
EP-0888111-B1 MODIFIED RELEASE MULTIPLE-UNITS DOSAGE COMPOSITION NYCOMED DANMARK AS (DK) 2003-05-21 EP disclosed
EP-1289493-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING DESGLYMIDODRINE AS AN ACTIVE DRUG SUBSTANCE Nycomed Austria GmbH (AT) 2003-03-12 EP disclosed
EP-1282406-A1 PHARMACEUTICAL KIT COMPRISING MIDODRINE AS AN ACTIVE DRUG SUBSTANCE Nycomed Austria GmbH (AT) 2003-02-12 EP disclosed
EP-1267841-A1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION CONTAINING MIDODRINE AND/OR DESGLYMIDODRINE Nycomed Austria GmbH (AT) 2003-01-02 EP disclosed
EP-0153104-B1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM BENZON PHARMA A/S (DK) 1993-04-21 EP disclosed
EP-0153105-B1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM BENZON PHARMA A/S (DK) 1992-09-09 EP disclosed
US-4716041-A SUSTAINED RELEASE A/S ALFRED BENZON (DK) 1987-12-29 US disclosed
US-4713248-A MIXTURE OF FILM FORMING AGENT WITH COMPRESSIBLE POLYMER A/S ALFRED BENZON (DK) 1987-12-15 US disclosed
EP-0153105-A2 Diffusion coated multiple-units dosage form BENZON PHARMA A/S (DK) 1985-08-28 EP disclosed
EP-0153104-A2 Diffusion coated multiple-units dosage form BENZON PHARMA A/S (DK) 1985-08-28 EP disclosed
WO-1985003436-A1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM A/S ALFRED BENZON (DK) 1985-08-15 WO disclosed
WO-1985003437-A1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM A/S ALFRED BENZON (DK) 1985-08-15 WO disclosed