Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6033408 | 0.79 | KDM4E (0.43) | IDO1KCNH2ALDH1A1HSD17B10KDM4E | |
| SCHEMBL4774603 | 0.74 | IDO1 (0.44) | IDO1KCNH2CYP2D6KDM4EMAPT | |
| SCHEMBL4774567 | 0.74 | KDM4E (0.34) | IDO1KCNH2CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL11888090 | 0.74 | KDM4E (0.39) | ALDH1A1HSD17B10CYP2C19KDM4EMAPT | |
| SCHEMBL31287151 | 0.73 | OPRK1 (0.40) | IDO1KCNH2ALDH1A1HSD17B10KDM4E | |
| SCHEMBL6034902 | 0.71 | IDO1 (0.48) | IDO1KCNH2KDM4ECYP2C9CYP3A4 | |
| SCHEMBL6033980 | 0.70 | ALDH1A1 (0.42) | IDO1KCNH2ALDH1A1KDM4EMAPT | |
| SCHEMBL4773023 | 0.70 | KDM4E (0.39) | IDO1KCNH2CYP2D6ALDH1A1HSD17B10 | |
| SCHEMBL7820992 | 0.69 | KDM4E (0.48) | ALDH1A1HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL5780853 | 0.68 | IDO1 (0.45) | IDO1KCNH2CYP2C9CYP3A4CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735320-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | claimed |
| WO-2005097806-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2005-10-20 | — | — | WO | claimed |