Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 12/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CETP | P11597 | 3/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780853 | 0.96 | IDO1 (0.45) | IDO1KCNH2CYP3A4CYP2C9CETP | |
| SCHEMBL4774603 | 0.79 | IDO1 (0.44) | IDO1KCNH2CYP3A4CYP2C9KDM4E | |
| SCHEMBL6033408 | 0.77 | KDM4E (0.43) | IDO1KCNH2CYP3A4CYP2C9KDM4E | |
| SCHEMBL6034336 | 0.76 | CETP (0.52) | CETPBRD4 | |
| SCHEMBL6033980 | 0.75 | ALDH1A1 (0.42) | IDO1KCNH2CYP3A4CYP2C9KDM4E | |
| SCHEMBL30211951 | 0.75 | NOTUM (0.57) | CYP3A4CYP2C9ABHD6KDM4ESMN1; SMN2 | |
| SCHEMBL7832103 | 0.75 | NOTUM (0.57) | CYP3A4CYP2C9ABHD6KDM4ESMN1; SMN2 | |
| SCHEMBL6034226 | 0.74 | CETP (0.53) | CETP | |
| SCHEMBL6033964 | 0.71 | IDO1 (0.39) | IDO1KCNH2CYP3A4CYP2C9CETP | |
| SCHEMBL22397716 | 0.71 | MPO (0.41) | IDO1KCNH2CYP3A4CYP2C9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735320-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | claimed |
| WO-2005097806-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2005-10-20 | — | — | WO | claimed |