Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | TGM2 | P21980 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888170 | 0.88 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1KMT2ANPSR1PDE7A | |
| SCHEMBL14010913 | 0.84 | TGM2 (0.75) | SMN1; SMN2ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL18239988 | 0.81 | PDE7A (1.00) | SMN1; SMN2ALDH1A1MEN1KMT2APDE7A | |
| SCHEMBL6037637 | 0.80 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL14573524 | 0.80 | MEN1 (0.64) | SMN1; SMN2ALDH1A1MEN1KMT2APDE7A | |
| SCHEMBL6034994 | 0.80 | TGM2 (0.72) | SMN1; SMN2ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL6034185 | 0.79 | TGM2 (1.00) | SMN1; SMN2ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL12290084 | 0.77 | ALOX15 (0.64) | SMN1; SMN2ALDH1A1MEN1KMT2APDE7A | |
| SCHEMBL6034989 | 0.76 | TGM2 (0.73) | SMN1; SMN2ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL6033420 | 0.76 | TGM2 (0.70) | ALDH1A1MEN1KMT2AMAPTTGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183759-A1 | Tissue transglutaminase inhibitors | BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | 2006-08-17 | — | — | US | disclosed |
| WO-2006060702-A1 | SUBSTITUED 3,4-DIHYDROTHIENO [2,3-D] PYRMIDINES AS TISSUE TRANSGLUTAMINASE INHIBITORS | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183759-A1 | Tissue transglutaminase inhibitors | TGM2, HNMT, TPMT | SMN1; SMN2 1897/4885ALDH1A1 3116/4885MEN1 2068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.