Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1584771 | 0.80 | PDCD1 (0.37) | PPARGPPARDPPARAPDCD1CD274 | |
| SCHEMBL17221218 | 0.77 | ERN1 (0.40) | PDCD1CD274PDE4APDE4BPDE4C | |
| SCHEMBL31146042 | 0.77 | ALDH1A1 (0.42) | PPARGPDCD1CD274PDE4APDE4B | |
| SCHEMBL3168281 | 0.74 | ACHE (0.41) | CYP3A4MEN1KMT2ATSHRCA2 | |
| SCHEMBL8477695 | 0.74 | LMNA (0.42) | PDCD1CD274CYP3A4TSHRCA2 | |
| SCHEMBL10604743 | 0.74 | PDE4A (0.44) | PPARGPPARDPPARAPDE4APDE4B | |
| SCHEMBL8897402 | 0.73 | MAPT (0.49) | PPARGPPARAPDE4DCA2ALDH1A1 | |
| SCHEMBL25550103 | 0.72 | PDCD1 (0.44) | PPARGPPARDPPARAPDCD1CD274 | |
| SCHEMBL13027439 | 0.72 | PDCD1 (0.37) | PPARGPPARDPPARAPDCD1CD274 | |
| SCHEMBL16963809 | 0.72 | GCGR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709000-A1 | PIPERIDINE DERIVATIVES AS GCS INHIBITORS | Celltech R&D Limited (GB) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068426-A1 | PIPERIDINE DERIVATIVES AS GCS INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-07-28 | — | — | WO | disclosed |