Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038763 | 0.89 | GCK (0.40) | PPARG | |
| SCHEMBL5107640 | 0.83 | KDR (0.40) | KDRKCNH2TNNI3KPPARG | |
| SCHEMBL6038797 | 0.82 | LOXL2 (0.37) | KDRKCNH2TNNI3K | |
| SCHEMBL6038700 | 0.82 | MAP2K7 (0.40) | KDRKCNH2TNNI3K | |
| SCHEMBL13999413 | 0.80 | KDR (0.51) | KDRKCNH2TNNI3K | |
| SCHEMBL5107630 | 0.80 | KDR (0.55) | KDRKCNH2TNNI3K | |
| SCHEMBL6517430 | 0.75 | GCK (0.37) | PPARG | |
| SCHEMBL5107641 | 0.74 | MAP2K7 (0.37) | KDRKCNH2 | |
| SCHEMBL5101452 | 0.74 | GCK (0.40) | — | |
| SCHEMBL5115233 | 0.74 | KDR (0.46) | KDRKCNH2TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-01-05 | — | — | US | disclosed |
| EP-1522540-A1 | AZAARENE DERIVATIVES | Eisai Co., Ltd. (JP) | 2005-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | KDR 1940/4885KCNH2 955/4885TNNI3K 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.