Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.34 |
| ▸ | GABRE | P78334 | 2/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1794002 | 0.87 | F2 (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1097728 | 0.86 | MLYCD (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1099319 | 0.84 | F2 (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18291311 | 0.81 | HDAC1 (0.34) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1097834 | 0.79 | PAX8 (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL22544386 | 0.76 | PIK3CA (0.38) | ALOX5APFEN1 | |
| SCHEMBL1099493 | 0.76 | USP30 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5187166 | 0.76 | KDM4E (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL22544369 | 0.74 | PKM (0.38) | ALOX5APFEN1 | |
| SCHEMBL28037370 | 0.74 | ALOX5AP (0.47) | ALOX5APFEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1420784-B1 | COMPOUNDS EFFECTING GLUCOKINASE | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |