Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRE | P78334 | 2/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097834 | 0.81 | PAX8 (0.44) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1099493 | 0.81 | USP30 (0.43) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1097728 | 0.78 | MLYCD (0.39) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8588375 | 0.76 | MIF (0.38) | PAX8 | |
| SCHEMBL2968367 | 0.76 | MMP2 (0.41) | KDM4EF2 | |
| SCHEMBL6614128 | 0.76 | ALDH1A1 (0.36) | HSD17B10F2 | |
| SCHEMBL1099319 | 0.76 | F2 (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1098537 | 0.76 | ALOX5AP (0.36) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6040385 | 0.76 | TP53 (0.35) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30978125 | 0.75 | F2 (0.33) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802591-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040520-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |