Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378249 | 0.85 | KCNH2 (0.71) | KCNH2KIF11 | |
| SCHEMBL3883041 | 0.84 | KIF11 (0.67) | KCNH2KIF11 | |
| SCHEMBL3887224 | 0.80 | KIF11 (0.53) | KCNH2KIF11 | |
| SCHEMBL3884591 | 0.80 | KIF11 (0.62) | KCNH2KIF11 | |
| SCHEMBL3881283 | 0.80 | KIF11 (0.59) | KCNH2KIF11 | |
| SCHEMBL3881801 | 0.79 | KIF11 (0.65) | KCNH2KIF11 | |
| SCHEMBL3863475 | 0.77 | KIF11 (0.61) | KCNH2KIF11 | |
| SCHEMBL3894544 | 0.77 | KIF11 (0.56) | KCNH2KIF11 | |
| SCHEMBL3894868 | 0.76 | KIF11 (0.67) | KCNH2KIF11 | |
| Trifluoroacetic Acid SCHEMBL4364775 | 0.76 | KIF11 (0.55) | KCNH2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058327-A1 | Kinesin spindle protein inhibitor; antiproliferative agents; anticancer agents; 4-(2,5-difluorophenyl)-N-3-fluoropyrrolidin-3-yl)-2-hydroxymethyl-2-phenyl-2,5-diphdro-1N-pyrrol-1-carboxamide | MERCK SHARP & DOHME CORP. | 2006-03-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058327-A1 | Kinesin spindle protein inhibitor; antiproliferative agents; anticancer agents; 4-(2,5-difluorophenyl)-N-3-fluoropyrrolidin-3-yl)-2-hydroxymethyl-2-phenyl-2,5-diphdro-1N-pyrrol-1-carboxamide | KIF5B, KIF2C, KIFC1 | KCNH2 1272/4885KIF11 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.