Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 7/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.41 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | PPARA | Q07869 | 6/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6931988 | 0.98 | PPARD (0.44) | PPARDLCKZDHHC20ZDHHC2CES2 | |
| SCHEMBL7776233 | 0.98 | PPARD (0.44) | PPARDLCKZDHHC20ZDHHC2CES2 | |
| SCHEMBL7530157 | 0.98 | PPARD (0.44) | PPARDLCKZDHHC20ZDHHC2CES2 | |
| SCHEMBL11156087 | 0.98 | PPARD (0.44) | PPARDLCKZDHHC20ZDHHC2CES2 | |
| SCHEMBL6045545 | 0.93 | PPARD (0.38) | PPARDLCKZDHHC20ZDHHC2AKR1B1 | |
| SCHEMBL27520410 | 0.89 | PPARD (0.47) | PPARDLCKZDHHC20ZDHHC2CES2 | |
| SCHEMBL28985021 | 0.87 | PPARD (0.45) | PPARDLCKZDHHC20ZDHHC2CES2 | |
| SCHEMBL12003172 | 0.85 | PPARD (0.44) | PPARDLCKZDHHC20ZDHHC2CES2 | |
| SCHEMBL1732567 | 0.84 | MEN1 (0.35) | PPARDLCKZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL1732836 | 0.84 | MEN1 (0.35) | PPARDLCKZDHHC20ZDHHC2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252774-A1 | Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases | NEW JERSEY, UNIVERSITY OF MEDICINE AND DENTISTRY OF | 2006-11-09 | — | — | US | disclosed |
| US-6887880-B2 | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-05-03 | — | — | US | disclosed |
| US-20020068745-A1 | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2002-06-06 | — | — | US | disclosed |
| WO-2002040481-A2 | ADENINE BASED INHIBITORS OF ADENYLYL CYCLASE, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
| EP-1203767-A1 | Heterocyclic-substituted alkylamide acat inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6288086-B1 | COMPOUNDS SUCH AS 1-METHYL-4-(4-BUTOXY-BENZENESULFONYL) -PIPERIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE USED TO TREAT ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, ETC.; LOW MOLECULAR WEIGHT AND NON-PEPTIDAL | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | disclosed |
| US-5693657-A | USEFUL FOR TREATING HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| US-5646170-A | ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0600950-B1 | AMIDE TETRAZOLE ACAT INHIBITORS | WARNER LAMBERT CO (US) | 1996-10-23 | — | — | EP | disclosed |
| US-5521218-A | Nanoparticulate iodipamide derivatives for use as x-ray contrast agents | NANOSYSTEMS L.L.C. (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0684945-A1 | HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5472946-A | Topical administration of lincomycin, clindamycin, erthromycin and iododeoxyuridine on skin or mucuous membranes | DISCOVERY THERAPEUTICS, INC. | 1995-12-05 | — | — | US | disclosed |
| US-5441975-A | Anticholesterol agent | WARNER-LAMBERT COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| US-5366987-A | Enzyme inhibitors, anticholesterol | WARNER-LAMBERT COMPANY (US) | 1994-11-22 | — | — | US | disclosed |
| WO-1994019330-A1 | HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-09-01 | — | — | WO | disclosed |
| EP-0600950-A1 | AMIDE TETRAZOLE ACAT INHIBITORS. | WARNER LAMBERT CO (US) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993004052-A1 | AMIDE TETRAZOLE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |
| EP-0156245-A1 | 7-oxabicycloheptane substituted prostaglandin interphenylene analogs | E.R. Squibb & Sons, Inc. (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4536513-A | 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of thrombolytic disease | E. R. SQUIBB & SONS, INC. (US) | 1985-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068745-A1 | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof | CD38, ADCY1, ADCY2 | PPARD 4533/4885LCK 3000/4885ZDHHC20 1488/4885 |
| US-20060252774-A1 | Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases | ADCY5, ADCY6, ADCY2 | PPARD 4028/4885LCK 3621/4885ZDHHC20 716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.