Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.58 |
| ▸ | PI4KA | P42356 | 1/20 | 0.52 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.52 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | ADA | P00813 | 4/20 | 0.50 |
| ▸ | PDE2A | O00408 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045692 | 0.87 | ADORA2A (0.60) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL1741666 | 0.81 | ADA (0.66) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL6045670 | 0.80 | ADORA2A (0.61) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL1740447 | 0.80 | ADA (0.68) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL1740512 | 0.80 | ADA (0.68) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL27574162 | 0.79 | ADA (0.53) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL5049210 | 0.79 | ADORA2A (0.63) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL23091481 | 0.79 | ALDH1A1 (0.51) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL3949676 | 0.76 | ADORA2A (0.68) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL22759880 | 0.76 | ADA (0.63) | ADORA2AADORA2BADORA1PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252774-A1 | Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases | NEW JERSEY, UNIVERSITY OF MEDICINE AND DENTISTRY OF | 2006-11-09 | — | — | US | disclosed |
| US-6887880-B2 | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-05-03 | — | — | US | disclosed |
| US-20020068745-A1 | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2002-06-06 | — | — | US | disclosed |
| WO-2002040481-A2 | ADENINE BASED INHIBITORS OF ADENYLYL CYCLASE, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068745-A1 | Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof | CD38, ADCY1, ADCY2 | ADORA2A 38/4885ADORA2B 52/4885ADORA1 27/4885 |
| US-20060252774-A1 | Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases | ADCY5, ADCY6, ADCY2 | ADORA2A 303/4885ADORA2B 691/4885ADORA1 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.