Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.42 |
| ▸ | ADCY5 | O95622 | 7/20 | 0.42 |
| ▸ | AHCY | P23526 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045701 | 1.00 | PI4KA (0.49) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL6045694 | 0.74 | PI4K2A (0.49) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL6045856 | 0.74 | PI4K2A (0.49) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL27437232 | 0.69 | PI4KA (0.54) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL10432167 | 0.69 | SLC28A1 (0.48) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL23969763 | 0.68 | PI4K2A (0.56) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL10669003 | 0.66 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL27438888 | 0.65 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL27599134 | 0.65 | GSK3B (0.69) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL30139991 | 0.64 | ADORA2A (0.48) | PI4KAPI4K2BPI4K2API4KBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252774-A1 | Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases | NEW JERSEY, UNIVERSITY OF MEDICINE AND DENTISTRY OF | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252774-A1 | Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases | ADCY5, ADCY6, ADCY2 | PI4KA 3192/4885PI4K2B 3248/4885PI4K2A 2756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.