Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.63 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.58 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4801160 | 0.90 | MAPT (0.56) | SIRT2SRD5A2SRD5A1MAPTKDM4E | |
| SCHEMBL1545660 | 0.81 | SIRT2 (0.58) | SIRT2MAPTKDM4ECRBNNPC1 | |
| SCHEMBL939611 | 0.81 | SMYD3 (0.59) | SRD5A2SRD5A1MAPTKDM4ECRBN | |
| SCHEMBL29995492 | 0.81 | SMYD3 (0.59) | SRD5A2SRD5A1MAPTKDM4ECRBN | |
| SCHEMBL28380734 | 0.80 | KDM4E (0.54) | SIRT2SRD5A2SRD5A1MAPTKDM4E | |
| Succinimide SCHEMBL9294241 | 0.80 | SMYD3 (0.58) | SRD5A2SRD5A1MAPTKDM4ECRBN | |
| SCHEMBL6046457 | 0.78 | SIRT2 (0.57) | SIRT2SRD5A2SRD5A1MAPTKDM4E | |
| SCHEMBL31304865 | 0.78 | KDM4E (0.53) | SIRT2SRD5A2SRD5A1MAPTKDM4E | |
| SCHEMBL940361 | 0.75 | MAPT (0.62) | MAPTKDM4ECRBNALDH1A1 | |
| SCHEMBL407439 | 0.75 | NPC1 (0.70) | SIRT2MAPTKDM4ENPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-10-26 | — | — | US | disclosed |
| EP-1547616-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-29 | — | — | EP | disclosed |
| EP-1537879-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | GPR4, HRH4, GPR3 | SIRT2 1088/4885SRD5A2 1274/4885SRD5A1 1326/4885 |
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | GPR4, TRPV1, TRPV4 | SIRT2 1886/4885SRD5A2 1943/4885SRD5A1 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.