Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL752388 | 0.82 | POLB (0.33) | MEN1KMT2AKCNN4TRPV1CNR2 | |
| SCHEMBL5603377 | 0.81 | TRPV1 (0.42) | TRPV1CNR2CNR1 | |
| SCHEMBL1121836 | 0.80 | NOTUM (0.35) | CNR2POLBSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL30343520 | 0.79 | POLB (0.32) | KCNN4TRPV1CNR2CNR1POLB | |
| SCHEMBL18982574 | 0.79 | NOTUM (0.34) | KCNN4POLBSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL653830 | 0.79 | CYP11B1 (0.33) | KCNN4POLBSMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL5641795 | 0.78 | CNR2 (0.38) | CNR2CYP11B1CYP11B2 | |
| SCHEMBL8131036 | 0.76 | DAGLA (0.32) | CYP11B1CYP11B2 | |
| SCHEMBL12327489 | 0.76 | DAGLA (0.35) | HTR2ASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL22832703 | 0.75 | IDO1 (0.36) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-10-26 | — | — | US | disclosed |
| EP-1547616-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-29 | — | — | EP | disclosed |
| EP-1537879-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | GPR4, HRH4, GPR3 | KDM4E 1411/4885CYP3A4 953/4885MAPT 4791/4885 |
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | GPR4, TRPV1, TRPV4 | KDM4E 1843/4885CYP3A4 4016/4885MAPT 3054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.