Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11874455 | 0.88 | IDO1 (0.51) | IDO1ALDH1A1MAPTTDP1THRB | |
| SCHEMBL3186176 | 0.77 | CYP3A4 (0.35) | CYP3A4POLB | |
| SCHEMBL7104703 | 0.75 | ELANE (0.31) | MAPTTDP1LMNACYP3A4CYP2D6 | |
| SCHEMBL27904725 | 0.75 | CYP3A4 (0.33) | CYP3A4 | |
| SCHEMBL16231160 | 0.69 | MAPT (0.50) | IDO1ALDH1A1MAPTTDP1THRB | |
| SCHEMBL8942748 | 0.68 | CASP3 (0.48) | IDO1ALDH1A1MAPTTDP1THRB | |
| SCHEMBL7188407 | 0.68 | LMNA (0.33) | LMNAALOX5PTGS1 | |
| SCHEMBL14894680 | 0.68 | MAPT (0.67) | IDO1ALDH1A1MAPTTDP1THRB | |
| SCHEMBL3420496 | 0.68 | MAPT (0.58) | IDO1ALDH1A1MAPTTDP1THRB | |
| SCHEMBL4318927 | 0.66 | LMNA (0.61) | IDO1ALDH1A1MAPTTDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7044945-B2 | Prevention of regression in thermal ciliary muscle tendinoplasty | SAND BRUCE J | 2006-05-16 | — | — | US | disclosed |
| US-20040093046-A1 | Prevention of regression in thermal ciliary muscle tendinoplasty | SAND BRUCE J | 2004-05-13 | — | — | US | disclosed |
| EP-0808103-A4 | PROTEIN HYDROXYLATION INHIBITORS FOR FIBROPROLIFERATIVE DISORDERS | CORNELL RES FOUNDATION INC (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000074648-A2 | PREVENTION OF REGRESSION IN REFRACTIVE KERATOPLASTY | SUNRISE TECHNOLOGIES INTERNATIONAL, INC. (US) | 2000-12-14 | — | — | WO | disclosed |
| US-6080766-A | ADMINISTERING TO A PATIENT AN EFFECTIVE AMOUNT OF A HYDROXYPYRROLIDONE COMPOUND TO SUPPRESS THE FORMATION OF COLLAGEN-LIKE SUBSTANCES OR BIOSYNTHESIS OF PROCOLLAGEN | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| US-6046219-A | ADMINISTERING TO THE PATIENT FOR TREATING THE CONDITIONS MEDIATED BY COLLAGEN FORMATION TOGETHER WITH CELL PROLIFERATION A HYDROXYPYRIDINE DERIVATIVE | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5965585-A | SUPPRESSING FORMATION OF COLLAGEN AND COLLAGEN-LIKE SUBSTANCES OR BIOSYNTHESIS OF PROCOLLAGEN IN LIVING SYSTEMS BY ADMINISTERING A HYDROXYPYRIDONE COMPOUND ENZYME INHIBITOR OF PROTEIN HYDROXYLASE; ANTISCARRING AGENTS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5965586-A | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5789426-A | SUPPRESSION FORMATION OF COLLAGEN | CORNELL RESEARCH FOUNDATION, INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0808103-A1 | PROTEIN HYDROXYLATION INHIBITORS FOR FIBROPROLIFERATIVE DISORDERS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996022021-A1 | PROTEIN HYDROXYLATION INHIBITORS FOR FIBROPROLIFERATIVE DISORDERS | CORNELL RESEARCH FOUNDATION, INC. (US) | 1996-07-25 | — | — | WO | disclosed |