Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4145649 | 0.76 | ALOX5 (0.38) | NOTUMMAPTTSHRNPC1SMN1; SMN2 | |
| SCHEMBL5886818 | 0.72 | CA12 (0.39) | MAPTNPC1SMN1; SMN2BACE1ESR2 | |
| SCHEMBL5821611 | 0.72 | DYRK1A (0.44) | NOTUMNR1I3MAPTSMN1; SMN2GAA | |
| SCHEMBL6047606 | 0.70 | NR1I3 (0.39) | NOTUMNR1I3MAPK10SLC6A3SLC6A2 | |
| SCHEMBL5887155 | 0.69 | NOTUM (0.36) | NOTUMNR1I3MAPK10SLC6A3SLC6A2 | |
| SCHEMBL4012821 | 0.68 | ESR2 (0.36) | NOTUMNR1I3MAPK10SLC6A3SLC6A2 | |
| SCHEMBL5887734 | 0.67 | RORB (0.36) | NOTUMPDE10A | |
| SCHEMBL5887105 | 0.67 | ESR2 (0.35) | NOTUMNR1I3MAPK10SLC6A3MAPT | |
| SCHEMBL5887750 | 0.66 | MAPK10 (0.38) | NOTUMNR1I3MAPK10MAPK9MAPK14 | |
| SCHEMBL6047598 | 0.66 | HTR2C (0.39) | NOTUMTSHRNPC1SMN1; SMN2ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006501194-A | — | — | 2006-01-12 | — | — | JP | claimed |
| EP-1525190-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-04-27 | — | — | EP | claimed |
| WO-2004007463-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-01-22 | — | — | WO | claimed |