Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047623 | 0.82 | ALDH1A1 (0.47) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL6047592 | 0.81 | ALOX5 (0.44) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5887069 | 0.77 | CA12 (0.38) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL5887487 | 0.77 | IDO1 (0.37) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL5887592 | 0.77 | ABL1 (0.39) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL5887439 | 0.77 | ABL1 (0.39) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL5887354 | 0.76 | SMN1; SMN2 (0.38) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL6047581 | 0.76 | ACHE (0.50) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5681041 | 0.75 | ABL1 (0.60) | NPC1RAB9AMAPTSMN1; SMN2ABL1 | |
| SCHEMBL5886818 | 0.72 | CA12 (0.39) | NPC1RAB9AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006501194-A | — | — | 2006-01-12 | — | — | JP | claimed |
| EP-1525190-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-04-27 | — | — | EP | claimed |
| WO-2004007463-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-01-22 | — | — | WO | claimed |