Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20717979 | 0.90 | NOS1 (0.68) | NOS1NPC1RAB9ASMN1; SMN2CYP2A6 | |
| SCHEMBL1397310 | 0.80 | IDO1 (0.65) | NOS1IDO1TAAR1NOS3NOS2 | |
| Carbamic Acid SCHEMBL2222080 | 0.79 | FFAR1 (0.62) | NOS1SMN1; SMN2CYP2A6HTR2ATAAR1 | |
| Urea SCHEMBL2006220 | 0.79 | FFAR1 (0.62) | NOS1SMN1; SMN2CYP2A6HTR2ATAAR1 | |
| SCHEMBL8534052 | 0.78 | NOS1 (0.53) | NOS1NPC1RAB9AIDO1SMN1; SMN2 | |
| SCHEMBL6882189 | 0.78 | ALDH1A1 (0.57) | NOS1IDO1SMN1; SMN2CYP2A6HTR2A | |
| SCHEMBL11686207 | 0.78 | NOS1 (0.53) | NOS1NPC1RAB9AIDO1SMN1; SMN2 | |
| SCHEMBL28338047 | 0.78 | NOS1 (0.53) | NOS1IDO1SMN1; SMN2CYP2A6HTR2A | |
| SCHEMBL17434763 | 0.78 | NOS1 (0.64) | NOS1CYP2D6NPC1CYP3A4RAB9A | |
| SCHEMBL29004556 | 0.78 | IDO1 (0.61) | NOS1NPC1IDO1SMN1; SMN2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101914124-B | Nucleoside phosphonate conjugates as anti HIV agents | GILEAD SCIENCES INC | 2012-07-18 | — | — | CN | disclosed |
| CN-101935333-A | Nucleoside phosphonate conjugates as anti-hiv agent | GILEAD SCIENCES INC | 2011-01-05 | — | — | CN | disclosed |
| CN-101914124-A | Nucleoside phosphonate conjugates as anti-hiv agent | GILEAD SCIENCES INC | 2010-12-15 | — | — | CN | disclosed |
| CN-101591281-A | Phosphonate compounds having immunomodulatory activity | GILEAD SCIENCES INC (US) | 2009-12-02 | — | — | CN | disclosed |
| CN-101381379-A | Kinase inhibitor phosphonate conjugates | GILEAD SCIENCES INC (US) | 2009-03-11 | — | — | CN | disclosed |
| CN-101027312-A | Antiviral compounds | GILEAD SCIENCES INC (US) | 2007-08-29 | — | — | CN | disclosed |
| US-20060264480-A1 | Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same | SUH YOUNG G | 2006-11-23 | — | — | US | disclosed |
| EP-1311477-A4 | NOVEL THIOCARBAMIC ACID DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORP (KR) | 2005-01-12 | — | — | EP | disclosed |
| US-20030203944-A1 | Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same | PACIFIC CORPORATION (KR) | 2003-10-30 | — | — | US | disclosed |
| EP-1311477-A1 | NOVEL THIOCARBAMIC ACID DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORPORATION (KR) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002016317-A1 | NOVEL THIOCARBAMIC ACID DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORPORATION (KR) | 2002-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264480-A1 | Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same | TRPV1, TRPA1, TRPV5 | NOS1 950/4885CYP2D6 893/4885NPC1 2332/4885 |
| US-20030203944-A1 | Novel thiocarbamic acid derivatives and the pharmaceutical compositions containing the same | TRPV1, TRPA1, TRPV5 | NOS1 950/4885CYP2D6 893/4885NPC1 2332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.