SCHEMBL6049396

SCHEMBL6049396

CCCNS(=O)(=O)NC(=O)c1cc(-n2c(=O)cc(C(F)(F)F)n(N)c2=O)ccc1Cl

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 4/20 0.35
CRHR2 Q13324 2/20 0.35
P2RX7 Q99572 5/20 0.33
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
ALDH1A1 P00352 2/20 0.32
LMNA P02545 1/20 0.32
APOBEC3A P31941 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
SCN9A Q15858 2/20 0.32
CTSB P07858 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NOTUM Q6P988 1/20 0.31
PDE4B Q07343 1/20 0.30
PDE4D Q08499 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6049440 0.94 P2RX7 (0.39) CRHR1CRHR2P2RX7ALDH1A1LMNA
SCHEMBL6049448 0.91 KCNA5 (0.34) CRHR1CRHR2P2RX7KMT2AALDH1A1
SCHEMBL6049379 0.89 TSHR (0.33) CRHR1CRHR2P2RX7KMT2AHSD17B10
SCHEMBL6049427 0.87 CRHR1 (0.33) CRHR1CRHR2P2RX7ALDH1A1LMNA
SCHEMBL6049357 0.85 SCN9A (0.31) SCN9A
SCHEMBL6049387 0.84 SCN9A (0.33) CRHR1CRHR2P2RX7KMT2AALDH1A1
SCHEMBL6049395 0.84 SCN9A (0.34) CRHR1CRHR2P2RX7KMT2AALDH1A1
SCHEMBL6049436 0.83 SCN9A (0.42) SCN9A
SCHEMBL6049378 0.83 SCN9A (0.35) P2RX7ALDH1A1LMNASCN9ACTSB
SCHEMBL6049359 0.83 P2RX7 (0.33) CRHR1CRHR2P2RX7ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1458237-B1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AG (DE) 2006-04-12 EP claimed
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AKTIENGESELLSCHAFT (DE) 2005-02-17 US claimed
EP-1458237-B1 HERBICIDAL MIXTURE BASED ON 7-PYRAZOLYLBENZOXAZOLES BASF AG (DE) 2006-04-12 EP disclosed
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles BASF AKTIENGESELLSCHAFT (DE) 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050037923-A1 Herbicidal mixture based on 7-pyrazolybenzoxazoles DDT, CYP2W1, CYP3A7 CRHR1 3847/4885CRHR2 4194/4885P2RX7 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.