Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | LOX | P28300 | 10/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 10/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668766 | 0.78 | RAF1 (0.69) | KDR | |
| SCHEMBL5576076 | 0.78 | BRAF (0.55) | LOXLOXL2KCNK3KCNK9GRM5 | |
| SCHEMBL5575779 | 0.77 | BRAF (0.57) | — | |
| SCHEMBL1619128 | 0.76 | HPGD (0.49) | F10F2LOXLOXL2KDR | |
| SCHEMBL5571979 | 0.75 | BRAF (0.48) | LOXLOXL2GPR119 | |
| SCHEMBL7635169 | 0.75 | LOXL2 (0.67) | LOXLOXL2KCNK3KCNK9GRM5 | |
| SCHEMBL11304260 | 0.74 | F10 (0.56) | F10F2LOXLOXL2GRM5 | |
| SCHEMBL18049110 | 0.72 | LOXL2 (0.85) | LOXLOXL2 | |
| SCHEMBL6049657 | 0.72 | RAF1 (0.61) | F10KDR | |
| SCHEMBL4089354 | 0.71 | MITF (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041982-A4 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1041982-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032111-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |