Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 9/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6051960 | 0.94 | CDK1 (0.46) | CDK1CCNB1CCNKCDK12TDP1 | |
| SCHEMBL6052136 | 0.85 | CDK1 (0.38) | CDK1CCNB1CCNKCDK12CDK2 | |
| SCHEMBL6051982 | 0.84 | CDK1 (0.38) | CDK1CCNB1CCNKCDK12CYP19A1 | |
| SCHEMBL6051965 | 0.79 | PDE2A (0.57) | TDP1MAPTPDE2A | |
| SCHEMBL6052091 | 0.76 | CDK1 (0.39) | CDK1CCNB1CCNKCDK12TDP1 | |
| SCHEMBL7436563 | 0.73 | PDE2A (0.57) | CDK1CCNB1CCNB2CDK2CCNB3 | |
| SCHEMBL6051959 | 0.71 | PDE2A (0.63) | KDM4EPDE2A | |
| SCHEMBL7442300 | 0.69 | PDE2A (0.57) | CDK2PDE2A | |
| SCHEMBL7435951 | 0.67 | PDE2A (0.46) | KDM4EPDE2A | |
| SCHEMBL7436632 | 0.66 | PDE2A (0.53) | CDK1CCNB1KDM4EMAPTCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060229242-A1 | Composition comprising a pulmonary surfactant and a pde2 inhibitor | ALTANA PHAZMA AG (DE) | 2006-10-12 | — | — | US | claimed |
| EP-1660132-A1 | COMPOSITION COMPRISING A PULMONARY SURFACTANT AND A PDE2 INHIBITOR | ALTANA Pharma AG (DE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005021037-A1 | COMPOSITION COMPRISING A PULMONARY SURFACTANT AND A PDE2 INHIBITOR | ALTANA PHARMA AG (DE) | 2005-03-10 | — | — | WO | claimed |
| US-20060229242-A1 | Composition comprising a pulmonary surfactant and a pde2 inhibitor | ALTANA PHAZMA AG (DE) | 2006-10-12 | — | — | US | disclosed |
| EP-1660132-A1 | COMPOSITION COMPRISING A PULMONARY SURFACTANT AND A PDE2 INHIBITOR | ALTANA Pharma AG (DE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021037-A1 | COMPOSITION COMPRISING A PULMONARY SURFACTANT AND A PDE2 INHIBITOR | ALTANA PHARMA AG (DE) | 2005-03-10 | — | — | WO | disclosed |