Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 2/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10873019 | 0.89 | TTR (0.42) | TTRBCL2MCL1KMT2AMEN1 | |
| SCHEMBL8599050 | 0.88 | TTR (0.46) | TTRBCL2MCL1KMT2AMEN1 | |
| SCHEMBL5308077 | 0.81 | BCL2 (0.58) | BCL2MCL1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3912083 | 0.81 | TTR (0.55) | TTRBCL2MCL1KMT2AMEN1 | |
| SCHEMBL5306728 | 0.80 | MAPT (0.57) | TTRKMT2AMEN1CDC25BALDH1A1 | |
| SCHEMBL23212346 | 0.79 | TTR (0.57) | TTRBCL2MCL1KMT2AMEN1 | |
| SCHEMBL17554244 | 0.79 | TTR (0.53) | TTRBCL2MCL1KMT2AMEN1 | |
| SCHEMBL6036890 | 0.79 | ALDH1A1 (0.51) | TTRKMT2AMEN1ALDH1A1NPC1 | |
| Anthraquinone SCHEMBL16721014 | 0.79 | MEN1 (0.52) | TTRBCL2MCL1KMT2AMEN1 | |
| SCHEMBL7017642 | 0.76 | FABP3 (0.44) | KMT2AALDH1A1SMN1; SMN2TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272223-B1 | THERAPEUTIC AND DIAGNOSTIC LIGAND SYSTEMS COMPRISING TRANSPORT MOLECULE BINDING PROPERTIES AND MEDICAMENTS CONTAINING THE SAME | KTB TUMORFORSCHUNGS GMBH (DE) | 2006-05-31 | — | — | EP | disclosed |