Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9362051 | 0.91 | LMNA (0.43) | EPHX2NR1H4LMNARECQLALDH1A1 | |
| SCHEMBL6054529 | 0.85 | LMNA (0.49) | LMNARECQLGAAHSP90AA1HSP90AB1 | |
| SCHEMBL9417705 | 0.85 | ALDH1A1 (0.45) | EPHX2NR1H4LMNAALDH1A1GAA | |
| SCHEMBL8496233 | 0.84 | MAPT (0.55) | LMNAALDH1A1TSHRGAAALOX15 | |
| SCHEMBL6054514 | 0.84 | ALDH1A1 (0.41) | LMNARECQLALDH1A1TSHRGAA | |
| SCHEMBL8698399 | 0.79 | PTGS1 (0.49) | LMNAALDH1A1TSHRGAAALOX15 | |
| SCHEMBL6054593 | 0.77 | PTGS1 (0.50) | LMNAALDH1A1TSHRGAAALOX15 | |
| SCHEMBL8843748 | 0.75 | LMNA (0.66) | LMNARECQLALDH1A1TSHRGAA | |
| SCHEMBL8767800 | 0.74 | PPARA (0.52) | MAPTCYP3A4MEN1CYP1A2KMT2A | |
| SCHEMBL6054536 | 0.74 | MAPT (0.51) | NR1H4ALDH1A1GAAMAPTVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137948-B1 | METHODS AND COMPOSITIONS TO LOWER PLASMA CHOLESTEROL LEVELS | ATHEROGENICS INC (US) | 2006-05-10 | — | — | EP | disclosed |