Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6057240 | 1.00 | ALDH1A1 (0.50) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL18528944 | 0.90 | NFE2L2 (0.46) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL3209348 | 0.90 | NFE2L2 (0.46) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL28619294 | 0.85 | CDK4 (0.47) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL7185453 | 0.83 | LMNA (0.48) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL11698273 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL207554 | 0.80 | ALDH1A1 (0.62) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL29374052 | 0.80 | ALDH1A1 (0.62) | ALDH1A1CYP3A4HPGDHSD17B10TDP1 | |
| SCHEMBL6057068 | 0.78 | MEN1 (0.46) | ALDH1A1HPGDHSD17B10TDP1CYP1A2 | |
| SCHEMBL31168163 | 0.77 | CYP3A4 (0.50) | ALDH1A1CYP3A4HPGDTDP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248763-B1 | AROMATIC DI-KETO DERIVATIVES AS GLUCOSE-6-PHOSPHATE TRANSLOCASE INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-1090136-B1 | MUMBAISTATIN, A PROCESS FOR ITS PRODUCTION AND ITS USE AS A PHARMACEUTICAL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-05-31 | — | — | EP | disclosed |
| EP-0672660-B1 | Substituted cyclohexanol-esters, their use to treat illnesses and pharmaceutical preparations | SANOFI AVENTIS DEUTSCHLAND (DE) | 2005-11-09 | — | — | EP | disclosed |
| EP-1113808-A4 | A METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME | UNIV MELBOURNE (AU) | 2004-06-16 | — | — | EP | disclosed |
| EP-0973760-B1 | KODAISTATINS A, B, C AND D, A PROCESS FOR THEIR PRODUCTION AND THEIR USE | AVENTIS PHARMA GMBH (DE) | 2002-11-13 | — | — | EP | disclosed |
| EP-1248763-A2 | AROMATIC DI-KETO DERIVATIVES AS GLUCOSE-6-PHOSPHATE TRANSLOCASE INHIBITORS | Aventis Pharma Deutschland GmbH (DE) | 2002-10-16 | — | — | EP | disclosed |
| US-6380257-B1 | USED AS GLUCOSE-6-PHOSPHATE TRANSLOCASE INHIBITORS AND CAN BE USED IN THERAPY OF DIABETES MELLITUS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-30 | — | — | US | disclosed |
| US-6297043-B1 | MOLECULAR FORMULA OF C28 H20 O12; CULTURE PRODUCT FROM STREPTOMYCES WHICH INHIBITS GLUCOSE-6-PHOSPHATE TRANSLOCASE; ANTIDIABETIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-10-02 | — | — | US | disclosed |
| EP-1113808-A1 | A METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME | THE UNIVERSITY OF MELBOURNE (AU) | 2001-07-11 | — | — | EP | disclosed |
| WO-2001030736-A2 | AROMATIC DI-KETO DERIVATIVES AS GLUCOSE-6-PHOSPHATE TRANSLOCASE INHIBITORS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-05-03 | — | — | WO | disclosed |
| US-5719170-A | GLUCOSE-6-PHOSPHATASE INHIBITOR; ANTIDIABETIC AGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| US-5629311-A | ANTIDIABETIC AGENTS; TREATMENT OF DISEASES CHARACTERIZED BY ELEVATED GLUCOSE SECRETION OR ELEVATION OFGLUCOSE PHOSPHATASE SYSTEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-13 | — | — | US | disclosed |
| US-5567725-A | ANTIDIABETIC AGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-10-22 | — | — | US | disclosed |
| EP-0587088-B1 | Derivatives of substituted cyclohexane, their process of preparation and their application with the treatment of diseases | HOECHST AG (DE) | 1996-05-08 | — | — | EP | disclosed |
| US-5463062-A | Inhibitors of glucose-6-phosphatase system | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-31 | — | — | US | disclosed |
| EP-0672660-A2 | Substituted cyclohexanol-esters, their use to treat illnesses and pharmaceutical preparations | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-20 | — | — | EP | disclosed |
| US-5451573-A | Substituted cyclohexane derivatives for the treatment of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-19 | — | — | US | disclosed |
| EP-0671392-A1 | Substituted propane derivatives, process for their preparation and use of the compounds for the treatment of illnesses | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-13 | — | — | EP | disclosed |
| EP-0587087-A1 | Substituted cyclohexane derivatives for the treatment of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0587088-A1 | Derivatives of substituted cyclohexane, their process of preparation and their application with the treatment of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-16 | — | — | EP | disclosed |