SCHEMBL6058464

SCHEMBL6058464

COC(=O)C12CC3CC(C1)CC([N+](=O)[O-])(C3)C2

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.39
GLA P06280 1/20 0.38
THRB P10828 1/20 0.36
ALDH1A1 P00352 5/20 0.35
TSHR P16473 2/20 0.34
ABL1 P00519 1/20 0.34
RIN1 Q13671 1/20 0.34
MAPT P10636 1/20 0.33
LMNA P02545 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6231775 0.86 GLA (0.33) NPSR1GLAMAPT
SCHEMBL6230750 0.86 GLA (0.33) GLAMAPT
SCHEMBL6229909 0.84 NPSR1 (0.46) NPSR1ALDH1A1MAPTLMNA
SCHEMBL7450742 0.82 THRB (0.36) NPSR1THRBALDH1A1LMNA
SCHEMBL6231540 0.81 NPSR1 (0.50) NPSR1ALDH1A1TSHRABL1RIN1
SCHEMBL163027 0.81 NPSR1 (0.53) NPSR1GLATHRBALDH1A1TSHR
SCHEMBL5608271 0.80 PKM (0.45) THRBALDH1A1LMNA
SCHEMBL6227897 0.80 KMT2A (0.38) MAPT
SCHEMBL1578928 0.78 POLB (0.46) NPSR1GLATHRBALDH1A1TSHR
SCHEMBL6058382 0.78 MEN1 (0.48) NPSR1THRBALDH1A1TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0897747-B1 NITRATION OR CARBOXYLATION CATALYSTS DAICEL CHEM (JP) 2006-04-05 EP disclosed
EP-1574494-A1 Adamantane derivative Daicel Chemical Industries, Ltd. (JP) 2005-09-14 EP disclosed
EP-1574495-A1 Adamantane derivatives Daicel Chemical Industries, Ltd. (JP) 2005-09-14 EP disclosed
US-6468487-B1 SUCH AS N-HYDROXYPHTHALIMIDE; DIRECTLY AND EFFICIENTLY REACTING ADAMANTANE WITH NITROGEN OXIDE OR WITH CARBON MONOXIDE AND OXYGEN DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2002-10-22 US disclosed
EP-0897747-A1 NITRATION OR CARBOXYLATION CATALYSTS Daicel Chemical Industries, Ltd. (JP) 1999-02-24 EP disclosed