SCHEMBL6229909

SCHEMBL6229909

CCOC(=O)C12CC3CC(C1)CC([N+](=O)[O-])(C3)C2

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 3/20 0.46
LMNA P02545 2/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
L3MBTL1 Q9Y468 2/20 0.39
ALDH1A1 P00352 3/20 0.39
MAPK1 P28482 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
ATM Q13315 1/20 0.36
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6231540 0.89 NPSR1 (0.50) NPSR1LMNAMEN1KMT2AL3MBTL1
SCHEMBL6058464 0.84 NPSR1 (0.39) NPSR1LMNAALDH1A1MAPT
SCHEMBL691923 0.83 NPSR1 (0.61) NPSR1LMNAMEN1KMT2AL3MBTL1
Hydrochloric Acid SCHEMBL27039883 0.79 NPSR1 (0.54) NPSR1LMNAMEN1KMT2AL3MBTL1
SCHEMBL7450742 0.79 THRB (0.36) NPSR1LMNAMEN1KMT2AL3MBTL1
SCHEMBL5608298 0.77 ALDH1A1 (0.59) NPSR1LMNAMEN1KMT2AL3MBTL1
SCHEMBL6229698 0.77 LMNA (0.42) LMNAL3MBTL1ALDH1A1
SCHEMBL5608271 0.77 PKM (0.45) LMNAMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL1073543 0.76 LMNA (0.59) NPSR1LMNAMEN1KMT2AALDH1A1
SCHEMBL6058382 0.75 MEN1 (0.48) NPSR1LMNAMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1574495-A1 Adamantane derivatives Daicel Chemical Industries, Ltd. (JP) 2005-09-14 EP disclosed
EP-1574494-A1 Adamantane derivative Daicel Chemical Industries, Ltd. (JP) 2005-09-14 EP disclosed
US-6468487-B1 SUCH AS N-HYDROXYPHTHALIMIDE; DIRECTLY AND EFFICIENTLY REACTING ADAMANTANE WITH NITROGEN OXIDE OR WITH CARBON MONOXIDE AND OXYGEN DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2002-10-22 US disclosed
CN-1304398-A Process for preparation of nitro compound and method for removal of nitrogen dioxide DAICEL CHEM (JP) 2001-07-18 CN disclosed
EP-1099684-A1 PROCESS FOR THE PREPARATION OF NITRO COMPOUNDS AND METHOD FOR THE REMOVAL OF NITROGEN DIOXIDE Daicel Chemical Industries, Ltd. (JP) 2001-05-16 EP disclosed
EP-0897747-A1 NITRATION OR CARBOXYLATION CATALYSTS Daicel Chemical Industries, Ltd. (JP) 1999-02-24 EP disclosed