Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14998807 | 0.68 | IAPP (0.45) | TAAR1KDM4EALDH1A1HTR1AHTR2A | |
| SCHEMBL13771839 | 0.67 | LIMK1 (0.60) | KDM4EALDH1A1HTTHRH4 | |
| SCHEMBL606293 | 0.64 | MTNR1A (0.63) | TAAR1KDM4EALDH1A1HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL27581438 | 0.63 | MTNR1A (0.61) | TAAR1KDM4EALDH1A1HTR1AHTR2A | |
| SCHEMBL8082610 | 0.62 | HTR2A (0.48) | TAAR1KDM4EALDH1A1HTR1AHTR2A | |
| SCHEMBL604790 | 0.62 | HRH4 (0.37) | DHFRHRH4 | |
| SCHEMBL28814208 | 0.62 | DHFR (0.47) | DHFR | |
| Hydrochloric Acid SCHEMBL3343899 | 0.60 | DHFR (0.46) | DHFR | |
| SCHEMBL15985140 | 0.60 | TAAR1 (0.42) | TAAR1KDM4EALDH1A1HTR1AHTR2A | |
| SCHEMBL5101510 | 0.60 | TAAR1 (0.59) | TAAR1KDM4EALDH1A1HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120039913-A1 | Selective Histamine H4 Receptor Antagonists for the Treatment of Vestibular Disorders | INSERM (institut National de la Sante de la Recher Medicale) (FR) | 2012-02-16 | — | — | US | disclosed |
| EP-2382013-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-11-02 | — | — | EP | disclosed |