Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049190 | 0.76 | HTR3A (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL9052046 | 0.74 | BCHE (0.52) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL31435509 | 0.74 | TFPI2 (0.58) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7024843 | 0.74 | TFPI2 (0.58) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL6850905 | 0.73 | HTR3A (0.48) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3182983 | 0.73 | HPGD (0.41) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9050600 | 0.73 | KEAP1 (0.55) | TSHRNOTUM | |
| SCHEMBL1023584 | 0.73 | TSHR (0.59) | TFPI2TSHRRAB9ANOTUM | |
| SCHEMBL1023583 | 0.73 | TSHR (0.59) | TFPI2TSHRRAB9ANOTUM | |
| SCHEMBL6851375 | 0.72 | HTR3A (0.53) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006516977-A | — | — | 2006-07-13 | — | — | JP | claimed |
| EP-1567163-A4 | METHOD OF TREATING NAUSEA, VOMITING, RETCHING OR ANY COMBINATION THEREOF | DYNOGEN PHARMACEUTICALS INC (US) | 2006-01-18 | — | — | EP | claimed |
| EP-1567163-A2 | METHOD OF TREATING NAUSEA, VOMITING, RETCHING OR ANY COMBINATION THEREOF | Dynogen Pharmaceuticals Inc. (US) | 2005-08-31 | — | — | EP | claimed |
| WO-2004062624-A2 | METHOD OF TREATING NAUSEA, VOMITING, RETCHING OR ANY COMBINATION THEREOF | DYNOGEN PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | claimed |