Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061529 | 0.81 | PDE4D (0.40) | POLBSMN1; SMN2L3MBTL1NPC1MEN1 | |
| SCHEMBL5663447 | 0.79 | FDPS (0.44) | POLBSMN1; SMN2LMNANPC1KMT2A | |
| SCHEMBL6060960 | 0.77 | PDE4D (0.43) | POLBLMNAL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL6061553 | 0.74 | MAPT (0.41) | POLBSMN1; SMN2LMNAL3MBTL1NPC1 | |
| SCHEMBL5663721 | 0.74 | FDPS (0.39) | L3MBTL1KMT2ACYP2C19ALDH1A1GAA | |
| SCHEMBL9224803 | 0.74 | POLB (0.43) | POLBSMN1; SMN2LMNAL3MBTL1NPC1 | |
| SCHEMBL6060881 | 0.74 | GAA (0.43) | POLBLMNANPC1MEN1KMT2A | |
| SCHEMBL6310141 | 0.72 | ALPL (0.40) | POLBSMN1; SMN2NPC1MAPTALDH1A1 | |
| SCHEMBL6061237 | 0.72 | KCNA5 (0.44) | SMN1; SMN2LMNANPC1MEN1KMT2A | |
| SCHEMBL5662741 | 0.71 | FDPS (0.42) | L3MBTL1KMT2ACYP2C19ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482953-A4 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS INC (US) | 2006-12-13 | — | — | EP | claimed |
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | PHAN HIEU T (CH) | 2005-06-09 | — | — | US | claimed |
| EP-1482953-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | Ilex Products, Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| WO-2003068240-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS, INC. (US) | 2003-08-21 | — | — | WO | claimed |
| EP-1482953-A4 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS INC (US) | 2006-12-13 | — | — | EP | disclosed |
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | PHAN HIEU T (CH) | 2005-06-09 | — | — | US | disclosed |
| EP-1482953-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | Ilex Products, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003068240-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | APOB, APOL1, LDLR | POLB 1364/4885SMN1; SMN2 4674/4885LMNA 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.