Succinic Acid

Succinic Acid

SCHEMBL6061689

C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=C([O-])CCC(=O)[O-]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.46
HDAC4 P56524 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC9 Q9UKV0 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
CYP2C19 P33261 2/20 0.44
CYP1A2 P05177 2/20 0.44
ALDH1A1 P00352 2/20 0.44
TSHR P16473 2/20 0.44
CYP2D6 P10635 1/20 0.44
CA1 P00915 2/20 0.41
ALPL P05186 1/20 0.39
POLB P06746 1/20 0.39
ALPG P10696 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propionic Acid SCHEMBL11169478 0.88 CES2 (0.45) HDAC3HDAC4HDAC1HDAC7HDAC2
Bicarbonate SCHEMBL8437546 0.87 CA2 (0.42) CYP2C19CYP1A2ALDH1A1TSHRCYP2D6
Bicarbonate SCHEMBL11217064 0.87 CA2 (0.42) CYP2C19CYP1A2ALDH1A1TSHRCYP2D6
Acetic Acid SCHEMBL7872955 0.85 CA2 (0.41) CYP2C19CYP1A2ALDH1A1TSHRCYP2D6
Acetic Acid SCHEMBL9603211 0.85 CA2 (0.41) CYP2C19CYP1A2ALDH1A1TSHRCYP2D6
Acetic Acid SCHEMBL9603209 0.83 CA2 (0.39) CYP2C19CYP1A2ALDH1A1TSHRCYP2D6
Tetraphenylphosphonium SCHEMBL7944619 0.83 HDAC3 (0.48) HDAC3HDAC4HDAC1HDAC7HDAC2
Succinic Acid SCHEMBL679440 0.80 CYP2C19 (0.50) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL7579915 0.79 KMT2A (0.44) TSHRMAPK1
Benzoic Acid SCHEMBL7874749 0.79 CA2 (0.64) ALDH1A1TSHRCA1CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993004122-A1 POLYESTER COMPOSITIONS CONTAINING PHOSPHONIUM COMPOUNDS THE DOW CHEMICAL COMPANY (US) 1993-03-04 WO claimed
US-20060229400-A1 Powder coating matting agent comprising ester amide condensation product FLETCHER TIM 2006-10-12 US disclosed
US-20050288450-A1 Coating matting agent comprising amide condensation product FLETCHER TIM 2005-12-29 US disclosed
EP-1509561-A1 POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT Grace GmbH & Co. KG (DE) 2005-03-02 EP disclosed
WO-2003102048-A1 POWDER COATING MATTING AGENT COMPRISING ESTER AMIDE CONDENSATION PRODUCT GRACE GMBH & CO. KG (DE) 2003-12-11 WO disclosed
WO-1993004122-A1 POLYESTER COMPOSITIONS CONTAINING PHOSPHONIUM COMPOUNDS THE DOW CHEMICAL COMPANY (US) 1993-03-04 WO disclosed