Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 4/20 | 0.40 |
| ▸ | CES1 | P23141 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL1399930 | 0.90 | CYP1A2 (0.47) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Bicarbonate SCHEMBL11663344 | 0.90 | CYP1A2 (0.50) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Bicarbonate SCHEMBL1144353 | 0.90 | CYP1A2 (0.50) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Acetic Acid SCHEMBL328882 | 0.88 | TSHR (0.48) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Oxalic Acid SCHEMBL10577823 | 0.88 | CYP1A2 (0.48) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Acetic Acid SCHEMBL133341 | 0.88 | TSHR (0.48) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Stearic Acid SCHEMBL11514728 | 0.88 | CES2 (0.53) | CES2CES1CA1PPARG | |
| Acetic Acid SCHEMBL328881 | 0.86 | TSHR (0.47) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Acetic Acid SCHEMBL9467718 | 0.86 | TSHR (0.47) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR | |
| Acetic Acid SCHEMBL10484555 | 0.86 | CYP1A2 (0.47) | CYP2C19ALDH1A1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 373 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2954011-A1 | ULTRA LOW CURE POWDER COATING | Valspar Sourcing, Inc. (US) | 2015-12-16 | — | — | EP | claimed |
| EP-2585473-B1 | METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF | ICL IP AMERICA INC (US) | 2015-09-23 | — | — | EP | claimed |
| EP-2510035-B1 | HYDROXYL-FUNCTIONAL POLYESTER RESINS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-08-05 | — | — | EP | claimed |
| US-8975343-B2 | Hydroxyl-functional polyester resins | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-03-10 | — | — | US | claimed |
| US-20150024194-A1 | ULTRA LOW CURE POWDER COATINGS | VALSPAR SOURCING, INC. (US) | 2015-01-22 | — | — | US | claimed |
| US-8889773-B2 | Metal phosphonate flame retardant and method producing thereof | ICL-IP AMERICA INC. (US) | 2014-11-18 | — | — | US | claimed |
| WO-2014123534-A1 | ULTRA LOW CURE POWDER COATING | VALSPAR SOURCING, INC. (US) | 2014-08-14 | — | — | WO | claimed |
| US-20130165564-A1 | METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF | ICL-IP AMERICA INC. (US) | 2013-06-27 | — | — | US | claimed |
| WO-2013077989-A1 | PROCESS FOR PREPARATION OF ALUMINUM SALT OF PHOSPHONIC ACID ESTER | ICL-IP AMERICA INC. (US) | 2013-05-30 | — | — | WO | claimed |
| EP-2585473-A2 | METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF | ICL-IP America Inc. (US) | 2013-05-01 | — | — | EP | claimed |
| US-6555628-B2 | Controlled conversion resins derived from reacting epoxy resin, dihydric phenol, acid anhydride, and/or amine; protective/powder coatings | DOW GLOBAL TECHNOLOGIES INC. | 2003-04-29 | — | — | US | claimed |
| US-20020128428-A1 | Epoxy resins and process for making the same | DOW DEUTSCHLAND INC. (DE) | 2002-09-12 | — | — | US | claimed |
| WO-2002048234-A2 | EPOXY RESINS AND PROCESS FOR MAKING THE SAME | DOW GLOBAL TECHNOLOGIES INC. (US) | 2002-06-20 | — | — | WO | claimed |
| US-6284845-B1 | POWDERED COATING COMPOSITION WHICH INCLUDES A CARBOXYL TERMINATED POLYESTER, EPOXY COMPOUNDS AND AN ONIUM CATALYST OR BETA-HYDROXYALKYLAMIDE | MCWHORTER TECHNOLOGIES | 2001-09-04 | — | — | US | claimed |
| US-5637654-A | ONIUM CURING CATALYST; LOW TEMPERATURE CURING, HARDNESS, FLEXIBILITY | MCWHORTER TECHNOLOGIES (US) | 1997-06-10 | — | — | US | claimed |
| WO-1993004122-A1 | POLYESTER COMPOSITIONS CONTAINING PHOSPHONIUM COMPOUNDS | THE DOW CHEMICAL COMPANY (US) | 1993-03-04 | — | — | WO | claimed |
| EP-0065564-B1 | METHOD FOR PREPARING HIGH MOLECULAR WEIGHT EPOXY RESINS CONTAINING HYDROLYZED GLYCIDYL GROUPS | THE DOW CHEMICAL COMPANY (US) | 1986-04-02 | — | — | EP | claimed |
| EP-0111562-A4 | PROCESS FOR PREPARING ADVANCED EPOXY RESINS EMPLOYING A PHOSPHONIUM TRIFLUOROACETATE CATALYST. | DOW CHEMICAL CO (US) | 1984-10-16 | — | — | EP | claimed |
| EP-0111562-A1 | PROCESS FOR PREPARING ADVANCED EPOXY RESINS EMPLOYING A PHOSPHONIUM TRIFLUOROACETATE CATALYST | THE DOW CHEMICAL COMPANY (US) | 1984-06-27 | — | — | EP | claimed |
| WO-1984000171-A1 | PROCESS FOR PREPARING ADVANCED EPOXY RESINS EMPLOYING A PHOSPHONIUM TRIFLUOROACETATE CATALYST | DOW CHEMICAL CO (US) | 1984-01-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165564-A1 | METAL PHOSPHONATE FLAME RETARDANT AND METHOD PRODUCING THEREOF | MTAP, AS3MT, MPHOSPH6 | CYP2C19 3855/4885ALDH1A1 2973/4885CYP1A2 4254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.