Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.46 |
| ▸ | CTSL | P07711 | 8/20 | 0.40 |
| ▸ | MMP2 | P08253 | 6/20 | 0.37 |
| ▸ | MMP1 | P03956 | 5/20 | 0.37 |
| ▸ | MMP3 | P08254 | 5/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5703798 | 0.87 | CTSS (0.44) | CTSSCTSLMMP2MMP1MMP3 | |
| SCHEMBL7259493 | 0.85 | CTSS (0.45) | CTSSCTSLMMP2MMP1MMP3 | |
| SCHEMBL5946322 | 0.83 | CTSS (0.40) | CTSSCTSLCTSK | |
| SCHEMBL5946098 | 0.83 | CTSS (0.40) | CTSSCTSLCTSK | |
| SCHEMBL5946093 | 0.83 | CTSS (0.40) | CTSSCTSLCTSK | |
| Hydrochloric Acid SCHEMBL7255797 | 0.79 | CTSS (0.47) | CTSSCTSLMMP2MMP1MMP3 | |
| SCHEMBL7255828 | 0.77 | CTSS (0.48) | CTSSCTSLMMP2MMP1MMP3 | |
| SCHEMBL6206920 | 0.74 | CTSS (0.41) | CTSS | |
| SCHEMBL7260348 | 0.74 | CTSS (0.35) | CTSS | |
| SCHEMBL7259168 | 0.74 | CTSS (0.43) | CTSSCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |