Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7255797 | 0.85 | CTSS (0.47) | CTSSLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6206025 | 0.80 | MAPT (0.39) | CTSSMAPT | |
| SCHEMBL7255683 | 0.78 | LMNA (0.36) | CTSSLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL6206918 | 0.77 | METAP2 (0.40) | CTSSLMNASMN1; SMN2HTTTSHR | |
| SCHEMBL7259168 | 0.77 | CTSS (0.43) | CTSSLMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL7259271 | 0.76 | CTSK (0.35) | LMNASMN1; SMN2HTTMAPTALDH1A1 | |
| SCHEMBL6633248 | 0.76 | LMNA (0.35) | CTSSLMNASMN1; SMN2HTTMAPT | |
| SCHEMBL6063534 | 0.75 | CTSS (0.38) | CTSSLMNASMN1; SMN2HTTTSHR | |
| SCHEMBL6063537 | 0.75 | CTSS (0.36) | CTSSLMNASMN1; SMN2HTTTSHR | |
| SCHEMBL6061967 | 0.74 | CTSS (0.46) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503997-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097617-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |