Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 6/20 | 0.40 |
| ▸ | CTSS | P25774 | 6/20 | 0.40 |
| ▸ | CTSL | P07711 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547881 | 0.88 | CTSB (0.41) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6062766 | 0.87 | CTSS (0.39) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6062942 | 0.87 | CTSL (0.40) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6737516 | 0.86 | CTSS (0.39) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL7658551 | 0.85 | CTSL (0.52) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL1558021 | 0.84 | CTSL (0.46) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6741608 | 0.84 | CTSL (0.46) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6061943 | 0.83 | CTSB (0.48) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL7682674 | 0.83 | CTSB (0.46) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL1557816 | 0.83 | CTSB (0.42) | CTSBCTSSCTSLCTSKCTSF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |