Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 13/20 | 0.42 |
| ▸ | CTSK | P43235 | 12/20 | 0.42 |
| ▸ | CTSL | P07711 | 6/20 | 0.41 |
| ▸ | CTSB | P07858 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6062163 | 0.83 | CTSS (0.46) | CTSSCTSKCTSLCTSB | |
| SCHEMBL6062786 | 0.83 | CTSK (0.41) | CTSSCTSKCTSLCTSBALDH1A1 | |
| SCHEMBL6063061 | 0.83 | CTSK (0.43) | CTSSCTSKCTSLCTSBALDH1A1 | |
| SCHEMBL6063208 | 0.81 | CTSL (0.41) | CTSSCTSKCTSLCTSBALDH1A1 | |
| SCHEMBL5526085 | 0.79 | CTSK (0.44) | CTSSCTSKCTSLCTSB | |
| SCHEMBL6062016 | 0.79 | CTSK (0.47) | CTSSCTSKCTSLCTSBALDH1A1 | |
| SCHEMBL6062154 | 0.79 | CTSK (0.44) | CTSSCTSKCTSLCTSBALDH1A1 | |
| SCHEMBL6061922 | 0.79 | CTSK (0.47) | CTSSCTSKCTSLCTSBALDH1A1 | |
| SCHEMBL6061608 | 0.76 | CTSL (0.40) | CTSSCTSKCTSLCTSBALDH1A1 | |
| SCHEMBL6632647 | 0.75 | CTSS (0.45) | CTSSCTSKCTSLCTSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | claimed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |