Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6062154 | 0.91 | CTSK (0.44) | CTSSALDH1A1CTSKL3MBTL1THRB | |
| SCHEMBL6062016 | 0.91 | CTSK (0.47) | CTSSALDH1A1CTSKL3MBTL1THRB | |
| SCHEMBL6061922 | 0.91 | CTSK (0.47) | CTSSALDH1A1CTSKL3MBTL1THRB | |
| SCHEMBL6630907 | 0.86 | KDM4E (0.41) | CTSSALDH1A1TSHRCTSKL3MBTL1 | |
| SCHEMBL6963901 | 0.82 | ALDH1A1 (0.51) | ALDH1A1TSHRL3MBTL1THRBATM | |
| SCHEMBL6955052 | 0.82 | ALDH1A1 (0.51) | ALDH1A1TSHRL3MBTL1THRBATM | |
| SCHEMBL6957348 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TSHRL3MBTL1THRBATM | |
| SCHEMBL5523888 | 0.82 | CTSS (0.52) | CTSSALDH1A1CTSKCTSBCTSL | |
| SCHEMBL6063061 | 0.79 | CTSK (0.43) | CTSSALDH1A1CTSKL3MBTL1CTSB | |
| SCHEMBL5526366 | 0.77 | L3MBTL1 (0.46) | CTSSALDH1A1CTSKL3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |