Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 11/20 | 0.42 |
| ▸ | FAAH | O00519 | 11/20 | 0.42 |
| ▸ | CES1 | P23141 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047937 | 0.84 | CTSS (0.39) | — | |
| SCHEMBL7048633 | 0.79 | DAGLA (0.48) | DAGLAFAAHCES1 | |
| SCHEMBL7048628 | 0.76 | CTSS (0.42) | DAGLAFAAHCES1 | |
| SCHEMBL6062834 | 0.76 | DAGLA (0.56) | DAGLAFAAHCES1 | |
| SCHEMBL6062952 | 0.75 | DAGLA (0.52) | DAGLAFAAHCES1 | |
| SCHEMBL7043323 | 0.75 | DAGLA (0.47) | DAGLAFAAHCES1 | |
| SCHEMBL6467918 | 0.75 | MMP2 (0.40) | SMN1; SMN2 | |
| SCHEMBL7047988 | 0.75 | FAAH (0.39) | DAGLAFAAHCES1 | |
| SCHEMBL6062592 | 0.74 | DAGLA (0.41) | DAGLAFAAHCES1 | |
| SCHEMBL6631047 | 0.74 | DAGLA (0.52) | DAGLAFAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |