Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 17/20 | 0.56 |
| ▸ | HTR1B | P28222 | 14/20 | 0.56 |
| ▸ | HTR1D | P28221 | 13/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218968 | 0.82 | HTR1D (0.77) | HTR1AHTR1BHTR1DCYP1A2HTR2A | |
| SCHEMBL5792934 | 0.82 | SLC6A4 (0.71) | HTR1AHTR1BHTR1DCYP1A2MAPT | |
| SCHEMBL26989198 | 0.81 | MAPT (0.58) | HTR1AHTR1BHTR1DCYP1A2MAPT | |
| SCHEMBL9329223 | 0.79 | SLC6A4 (0.69) | HTR1AHTR1BHTR1DCYP1A2MAPT | |
| SCHEMBL9828421 | 0.77 | HTR1D (0.67) | HTR1AHTR1BHTR1DCYP1A2SLC6A4 | |
| SCHEMBL23649345 | 0.76 | HTR2A (0.69) | HTR1AHTR1BHTR1DHTR2AHTR2C | |
| SCHEMBL27812733 | 0.76 | HTR1A (0.76) | HTR1AHTR1BHTR1DCYP1A2MAPT | |
| SCHEMBL27929459 | 0.75 | HTR2A (0.67) | HTR1AHTR1BHTR1DMAPTHTR2A | |
| SCHEMBL10646261 | 0.74 | HTR1D (0.57) | HTR1AHTR1BHTR1DCYP1A2BLM | |
| SCHEMBL9698903 | 0.74 | MTNR1A (0.56) | HTR1AHTR1BHTR1DCYP1A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680397-A2 | NOVEL COMPOUNDS AND THEIR USE AS ANTIDIABETIC AND HYPOLIPIDEMIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Reddy's Laboratories Ltd. (IN) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040102-A2 | NOVEL COMPOUNDS AND THEIR USE AS ANTIDIABETIC AND HYPOLIPIDEMIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2005-05-06 | — | — | WO | disclosed |