Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828421 | 0.92 | HTR1D (0.67) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL8538117 | 0.89 | CYP1A2 (0.56) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL9697617 | 0.87 | HTR1D (0.57) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL9698903 | 0.86 | MTNR1A (0.56) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL8538964 | 0.83 | HTR1A (0.48) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL9329223 | 0.81 | SLC6A4 (0.69) | HTR1DCYP1A2CYP2C9HTR1BHTR1A | |
| SCHEMBL9256337 | 0.81 | HTR7 (0.70) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL9827891 | 0.80 | HTR1D (0.67) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL9828299 | 0.80 | HTR1D (0.67) | HTR1DCYP1A2CYP2C9CYP2C19HTR1B | |
| SCHEMBL9264998 | 0.77 | HTR7 (0.72) | HTR1DCYP1A2CYP2C9HTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |