Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064373 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL11439813 | 0.77 | CES2 (0.45) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL11439809 | 0.77 | CES2 (0.45) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL4373394 | 0.76 | ESR2 (0.43) | ALDH1A1KDM4ELMNANPSR1MAPK1 | |
| SCHEMBL8288329 | 0.76 | ESR2 (0.43) | ALDH1A1KDM4ELMNANPSR1MAPK1 | |
| SCHEMBL4373391 | 0.76 | ESR2 (0.43) | ALDH1A1KDM4ELMNANPSR1MAPK1 | |
| SCHEMBL16911507 | 0.71 | HNF4A (0.58) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL23078744 | 0.71 | SLC6A3 (0.51) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL17799572 | 0.70 | HNF4A (0.56) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL9285511 | 0.69 | HNF4A (0.46) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |