Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498488 | 0.80 | HDAC1 (0.35) | HTTPOLBSMN1; SMN2KMT2ARAB9A | |
| SCHEMBL3120670 | 0.77 | PKM (0.47) | SMN1; SMN2TSHRKMT2ARAB9AMEN1 | |
| SCHEMBL5497757 | 0.76 | BRD9 (0.36) | SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL27620832 | 0.72 | CETP (0.44) | HTTNCOA1NCOA3CETPPOLB | |
| SCHEMBL5651536 | 0.72 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2ARAB9AMEN1MAPK10 | |
| SCHEMBL9128150 | 0.71 | CETP (0.48) | HTTNCOA1NCOA3CETPPOLB | |
| SCHEMBL17853274 | 0.71 | CNR2 (0.34) | HTTSMN1; SMN2KMT2AMEN1L3MBTL1 | |
| SCHEMBL5500017 | 0.70 | TLR7 (0.36) | KDM4EALDH1A1CA1CA2LMNA | |
| SCHEMBL30757446 | 0.70 | TSHR (0.52) | HTTNCOA1NCOA3SMN1; SMN2TSHR | |
| SCHEMBL16592882 | 0.70 | KAT2B (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663245-A1 | CEPHEM COMPOUNDS | Astellas Pharma Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005027909-A1 | CEPHEM COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2005-03-31 | — | — | WO | disclosed |